Both players suffered the injuries during training this week and will also miss the Champions League clash with Celtic on Tuesday.
A statement from Milan read: “AC Milan announces Cristian Zaccardo has suffered a sprain in his left ankle.
“The defender’s condition will be evaluated in the next coming days to determine a prognosis.
“Marco Amelia will undergo surgery in his left knee today (Friday) having sustained a meniscus injury.”
The Rossoneri are currently 10th in the Serie A.
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Liverpool have unveiled their new home kit for next season, sticking with the hugely popular retro styling of the current shirt.
The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.