Aguero is nursing an injury, as is new Boca Juniors signing Gago, for the friendly in Rome next month.
Not a single player from the Argentine league has been selected, with Monterrey’s Jose Basanta the only selection from outside Europe.
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Since Guus Hiddink arrived at the helm, Chelsea have improved considerably after a tricky start to the campaign.
Newcastle United are staring down the barrel of relegation to the Championship for the second time in the past eight years.