Aguero is nursing an injury, as is new Boca Juniors signing Gago, for the friendly in Rome next month.
Not a single player from the Argentine league has been selected, with Monterrey’s Jose Basanta the only selection from outside Europe.
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The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.
Five English clubs will compete in the last sixteen of the Champions League for the first time ever as Liverpool, Manchester United, Manchester City, Chelsea and Tottenham face some difficult away matches.