Two goals from Leo Messi and one from Sergio Aguero were enough to give the Argentines a crucial victory.
Argentina are now clear at the top of the South American rankings, with Uruguay down in joint fourth with Chile.
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Since Guus Hiddink arrived at the helm, Chelsea have improved considerably after a tricky start to the campaign.
Newcastle United are staring down the barrel of relegation to the Championship for the second time in the past eight years.