The Gunners star suffered the injury in the midweek Champions League play-off win over Fenerbahce.
“His hamstring is much more damaged than we thought at the start,” Arsenal boss Arsene Wenger said.
“It is very disappointing and we have paid a very heavy price for that win. We have to be patient now.”
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The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.
Five English clubs will compete in the last sixteen of the Champions League for the first time ever as Liverpool, Manchester United, Manchester City, Chelsea and Tottenham face some difficult away matches.