The forward was injured in the defeat to Brazil at the weekend, straining a muscle.
He is likely to be replaced by club mate Stephan el Shaarawy in the Italian line up.
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The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.
Five English clubs will compete in the last sixteen of the Champions League for the first time ever as Liverpool, Manchester United, Manchester City, Chelsea and Tottenham face some difficult away matches.