Barcelona had been 1-0 down at home to Sevilla before David Villa and Leo Messi struck to seal another big win for the league leaders.
Real were 1-0 down at Deportivo and being completely outplayed, but bounced back thanks to strikes from Kaka and Gonzalo Higuain.
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Since Guus Hiddink arrived at the helm, Chelsea have improved considerably after a tricky start to the campaign.
Newcastle United are staring down the barrel of relegation to the Championship for the second time in the past eight years.