The Argentine forward suffered an injury in the first leg last week in Paris.
With the tie 2-2 from the first game, and Messi showing signs he may be fit, Barcelona are hoping they can call on the player for the match.
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Summer 2016 is set to be a very exciting time for football fans, as this is when the long awaited Euro 2016 tournament kicks off.
Since Guus Hiddink arrived at the helm, Chelsea have improved considerably after a tricky start to the campaign.