Vilanova has been dogged by ill health and spent most of last season recovering from a cancerous tumour.
AS report that Vilanova is to be temporarily replaced by a new member of staff, called Rubi, who managed Girona in the Segunda Division last season.
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The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.
Five English clubs will compete in the last sixteen of the Champions League for the first time ever as Liverpool, Manchester United, Manchester City, Chelsea and Tottenham face some difficult away matches.