The Catalans were the better team throughout but went behind when Cristiano Ronaldo headed in a corner.
Goals from Pedro, a penalty from Leo Messi and a third from Xavi seemed to have given Vilanova a great win but Angel di Maria netted a second for Real to leave the tie on a knife edge going into the return.
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Summer 2016 is set to be a very exciting time for football fans, as this is when the long awaited Euro 2016 tournament kicks off.
Since Guus Hiddink arrived at the helm, Chelsea have improved considerably after a tricky start to the campaign.