The 2008 winners of the UEFA Cup were dispatched 2-1 on aggregate despite winning the second leg 1-0.
Lazio progressed after beating Stuttgart 2-0 and Benfica knocked out Bordeaux with a 3-2 win last night. Rubin Kazan progress after beating Levante and Fenerbahce complete the last eight.
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The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.
Five English clubs will compete in the last sixteen of the Champions League for the first time ever as Liverpool, Manchester United, Manchester City, Chelsea and Tottenham face some difficult away matches.