Bastian Schweinsteiger is suspended for the game after picking up a yellow card in a win over the same opponents on Friday.
And Julian Draxler, the Schalke playmaker, suffered concussion in the game, leaving Jogi Low short in midfield.
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Since Guus Hiddink arrived at the helm, Chelsea have improved considerably after a tricky start to the campaign.
Newcastle United are staring down the barrel of relegation to the Championship for the second time in the past eight years.