Real were beaten 2-1, with Benzema adding to their problems with Gonzalo Higuain already injured.
Jose Callejon, who came on for Benzema, could be asked to fill the centre forward berth.
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Who of Europe’s top strikers will move to England this summer?
After a dreadful start to their Bundesliga campaign, Borussia Dortmund appear to have weathered the storm after going five matches without defeat.