Casillas broke his hand during the 1-1 draw with Valencia in the Copa del Rey earlier this week.
Real are set to face United in the Champions League next month and Barcelona in the Copa del Rey semi final.
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The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.
Five English clubs will compete in the last sixteen of the Champions League for the first time ever as Liverpool, Manchester United, Manchester City, Chelsea and Tottenham face some difficult away matches.