Cathcart has failed to recover from a back injury that he sustained while playing for Blackpool in the 2-1 victory over Liverpool.
The 21-year-old did not feature for Northern ireland in the clash with Italy on Friday.
Northern Ireland remain unbeaten in the Euro 2012 qualifying Group C.
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Since Guus Hiddink arrived at the helm, Chelsea have improved considerably after a tricky start to the campaign.
Newcastle United are staring down the barrel of relegation to the Championship for the second time in the past eight years.