Cathcart has failed to recover from a back injury that he sustained while playing for Blackpool in the 2-1 victory over Liverpool.
The 21-year-old did not feature for Northern ireland in the clash with Italy on Friday.
Northern Ireland remain unbeaten in the Euro 2012 qualifying Group C.
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The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.
Five English clubs will compete in the last sixteen of the Champions League for the first time ever as Liverpool, Manchester United, Manchester City, Chelsea and Tottenham face some difficult away matches.