That is the highlight of the round, with other mouth watering ties including Arsenal v Bayern Munich and Shakhtar Donetsk v Borussia Dortmund.
Elsewhere, Barcelona will be favourites to beat AC Milan, Juventus likewise against Celtic and Schalke also against Galatasaray.
Paris St Germain take on Valencia and Porto face Malaga.
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Since Guus Hiddink arrived at the helm, Chelsea have improved considerably after a tricky start to the campaign.
Newcastle United are staring down the barrel of relegation to the Championship for the second time in the past eight years.