That is the highlight of the round, with other mouth watering ties including Arsenal v Bayern Munich and Shakhtar Donetsk v Borussia Dortmund.
Elsewhere, Barcelona will be favourites to beat AC Milan, Juventus likewise against Celtic and Schalke also against Galatasaray.
Paris St Germain take on Valencia and Porto face Malaga.
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The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.
Five English clubs will compete in the last sixteen of the Champions League for the first time ever as Liverpool, Manchester United, Manchester City, Chelsea and Tottenham face some difficult away matches.