City face Real Madrid on Wednesday needing to win to give themselves any chance of qualification for the last 16.
“We should never give up,” the Argentine said. “Where there’s a will, there’s a way, right?
“Of course, it’s harder now because we’re not just relying on ourselves but also on the other teams’ results.”
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The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.
Five English clubs will compete in the last sixteen of the Champions League for the first time ever as Liverpool, Manchester United, Manchester City, Chelsea and Tottenham face some difficult away matches.