Buffon was superb for Italy against Armenia on Friday but is a major doubt after suffering a thigh injury.
That means the pressure could be on de Sanctis to keep guard in a pivotal qualifier at the San Siro.
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The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.
Five English clubs will compete in the last sixteen of the Champions League for the first time ever as Liverpool, Manchester United, Manchester City, Chelsea and Tottenham face some difficult away matches.