Buffon was superb for Italy against Armenia on Friday but is a major doubt after suffering a thigh injury.
That means the pressure could be on de Sanctis to keep guard in a pivotal qualifier at the San Siro.
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Who of Europe’s top strikers will move to England this summer?
After a dreadful start to their Bundesliga campaign, Borussia Dortmund appear to have weathered the storm after going five matches without defeat.