Buffon was superb for Italy against Armenia on Friday but is a major doubt after suffering a thigh injury.
That means the pressure could be on de Sanctis to keep guard in a pivotal qualifier at the San Siro.
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Summer 2016 is set to be a very exciting time for football fans, as this is when the long awaited Euro 2016 tournament kicks off.
Since Guus Hiddink arrived at the helm, Chelsea have improved considerably after a tricky start to the campaign.