The big match could be pivotal as France travel to Madrid hoping to pick up a crucial point or three.
“We will not dwell on this, we will recover and prepare for the game on Tuesday,” said Deschamps.
“We have less to lose than Spain. It is not always the dominant team that wins.”
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The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.
Five English clubs will compete in the last sixteen of the Champions League for the first time ever as Liverpool, Manchester United, Manchester City, Chelsea and Tottenham face some difficult away matches.