Chelsea were outclassed by Shakhtar Donetsk in the Champions League in the week before losing at home to Manchester United on Sunday.
“We have to regroup first of all. We will have a few players missing after we played with nine men and in a week when we had a long trip to Ukraine”, Di Matteo told the official club website.
“I have to see how the players are tomorrow and think about what kind of team I put out on Wednesday.
“We know we have a good and strong team. We just have to ride this moment where we miss a few players, play in three days and get our energy back.”
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Since Guus Hiddink arrived at the helm, Chelsea have improved considerably after a tricky start to the campaign.
Newcastle United are staring down the barrel of relegation to the Championship for the second time in the past eight years.