Shakhtar Donetsk face the Premier League champions at the Donbass Arena on Wednesday evening.
“We have the opportunity to win this game,” Eduardo told The Sun.
“United may be in trouble but they are still strong and we have to concentrate.
“But they will be under pressure even if the teams have a different mentality in the Champions League and raise their game.
“We beat Arsenal here a few years ago and Chelsea last season. We always play very well at home.”
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The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.
Five English clubs will compete in the last sixteen of the Champions League for the first time ever as Liverpool, Manchester United, Manchester City, Chelsea and Tottenham face some difficult away matches.