Baines suffered a fractured toe in Saturday’s 3-3 draw with Liverpool.
Everton manager Roberto Martinez said: “It has been confirmed that Leighton has got a fracture in one of the bones in his right foot, which is the phalange.
“We need to treat that now and see how it develops. It could mean anything from missing six weeks to being back in 10 days because it depends how the fracture heals.
“It is in such a specific spot and we are going to see how it (the injury) reacts.”
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The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.
Five English clubs will compete in the last sixteen of the Champions League for the first time ever as Liverpool, Manchester United, Manchester City, Chelsea and Tottenham face some difficult away matches.