Ghana won 2-0 on Saturday after a tough fought game to book their last four place.
They will face the winner of the clash between Burkina Faso and Togo in the semi finals.
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The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.
Five English clubs will compete in the last sixteen of the Champions League for the first time ever as Liverpool, Manchester United, Manchester City, Chelsea and Tottenham face some difficult away matches.