A thrilling game saw Marseille go in front through Andre Ayew, before Emmanuel Herrera drew the visitors level.
John Utaka then put La Pallaide ahead, before Jordan Ayew equalised, and then Gignac scored late on to take the south coast club above arch rivals Paris St Germain.
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Who of Europe’s top strikers will move to England this summer?
After a dreadful start to their Bundesliga campaign, Borussia Dortmund appear to have weathered the storm after going five matches without defeat.