Gignac has been key for Marseille, scoring five times as they went top of the league, before losing that advantage to Paris St Germain.
A statement on the Marseille website read: “Andre-Pierre Gignac has suffered a fractured fifth metatarsal. He has been ruled out for six weeks, according to the medical staff of Marseille.”
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The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.
Five English clubs will compete in the last sixteen of the Champions League for the first time ever as Liverpool, Manchester United, Manchester City, Chelsea and Tottenham face some difficult away matches.