Neymar struck twice and Paulinho and Kaka also scored for the Brazilians.
Japan had beaten France 1-0 on Friday night, and the result underlines Brazil’s credentials ahead of the 2014 World Cup they host.
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The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.
Five English clubs will compete in the last sixteen of the Champions League for the first time ever as Liverpool, Manchester United, Manchester City, Chelsea and Tottenham face some difficult away matches.