Juve, the reigning Serie A champions, have not lost since the 2010-11 season and are top of the league.
Inter are just behind them after beating Sampdoria in midweek and will hope to end their run and keep up with the Bianconeri at the top of the table.
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The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.
Five English clubs will compete in the last sixteen of the Champions League for the first time ever as Liverpool, Manchester United, Manchester City, Chelsea and Tottenham face some difficult away matches.