Goals from Mirko Vucinic and Claudio Marchisio wrapped up the win for the Bianconeri.
The victory ended Bologna’s good run which had seen them beat Fiorentina and Inter Milan.
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The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.
Five English clubs will compete in the last sixteen of the Champions League for the first time ever as Liverpool, Manchester United, Manchester City, Chelsea and Tottenham face some difficult away matches.