It was their first ever defeat in their home stadium, opened last year.
Arturo Vidal had put them in front but goals from Diego Milito (2) and Rodrigo Palacio gave Inter three points that keeps them on Juve’s toes.
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Since Guus Hiddink arrived at the helm, Chelsea have improved considerably after a tricky start to the campaign.
Newcastle United are staring down the barrel of relegation to the Championship for the second time in the past eight years.