Dortmund, the German champions, lost 2-1 at home to Schalke on Saturday, leaving their title defence in tatters.
“We did not play well against Schalke and there is nothing we can do to change that,” said coach Juergen Klopp. “But the match against Real Madrid remains a cool game.”
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Since Guus Hiddink arrived at the helm, Chelsea have improved considerably after a tricky start to the campaign.
Newcastle United are staring down the barrel of relegation to the Championship for the second time in the past eight years.