The champions went ahead through Alvaro Morata before Ramos doubled the lead, but was then sent off for the 17th time in his career.
Atletico Madrid beat Valladolid to stay four points clear of their city rivals.
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The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.
Five English clubs will compete in the last sixteen of the Champions League for the first time ever as Liverpool, Manchester United, Manchester City, Chelsea and Tottenham face some difficult away matches.