The prodigious youngster has shone in the Champions League for the Andalucians this season, underlining his growing reputation.
A number of teams are keen to sign him, and according to El Mundo Deportivo Real Madrid President Florentino Perez is particularly keen on Isco.
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The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.
Five English clubs will compete in the last sixteen of the Champions League for the first time ever as Liverpool, Manchester United, Manchester City, Chelsea and Tottenham face some difficult away matches.