Ghana overcame Niger 3-0 to comfortably secure their passage as group winners to face Cape Verde in the last eight.
Mali fought back to draw 1-1 with DR Congo to ensure their place and a meeting with hosts South Africa in the quarter finals.
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Since Guus Hiddink arrived at the helm, Chelsea have improved considerably after a tricky start to the campaign.
Newcastle United are staring down the barrel of relegation to the Championship for the second time in the past eight years.