Fletcher returned to action for United in a benefit match against Aberdeen last month.
The Scotland skipper had been out of action since November last year due to a chronic inflammatory bowel condition.
It had been feared that Fletcher would never play again.
United have decided not to include Portuguese winger Bebe in their squad.
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Since Guus Hiddink arrived at the helm, Chelsea have improved considerably after a tricky start to the campaign.
Newcastle United are staring down the barrel of relegation to the Championship for the second time in the past eight years.