United missed out on the Germany midfielder in the summer window, but may try again in January.
The Mirror reports that United are considering making a £35million bid for Khedira in January.
United boss David Moyes sent assistant coach Phil Neville to watch Khedira in action in Real Madrid’s 7-3 home win over Sevilla last week.
Moyes is keen to bolster his midfield in January and Khedira would be able to come in and strengthen his side.
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Since Guus Hiddink arrived at the helm, Chelsea have improved considerably after a tricky start to the campaign.
Newcastle United are staring down the barrel of relegation to the Championship for the second time in the past eight years.