Smalling suffered the injury in training before the clash with rivals Liverpool at the weekend.
Nemanja Vidic is set to feature alongside Phil Jones for the clash with Olympiakos.
Rio Ferdinand could be set for a recall to the United team for the clash with Manchester City, as Vidic is banned for boths the clash with City and against West Ham.
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The start of the 2017-18 Premier League season is just around the corner and is shaping up to be one of the most competitive yet.
As always it is the so called “big clubs” that have splashed the most cash in the transfer window so far this summer. Manchester United or City? Arsenal or Tottenham? Who are the winners and losers of the transfer window so far?