Van Persie was forced off at half-time in Holland’s World Cup qualifier against Hungary.
Van Persie took two knees to the thigh in a challenge with Hungary defender Roland Juhasz.
The extent of the 29-year-old Dutchman’s injury has not yet been confirmed.
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Since Guus Hiddink arrived at the helm, Chelsea have improved considerably after a tricky start to the campaign.
Newcastle United are staring down the barrel of relegation to the Championship for the second time in the past eight years.