Van Persie was forced off at half-time in Holland’s World Cup qualifier against Hungary.
Van Persie took two knees to the thigh in a challenge with Hungary defender Roland Juhasz.
The extent of the 29-year-old Dutchman’s injury has not yet been confirmed.
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The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.
Five English clubs will compete in the last sixteen of the Champions League for the first time ever as Liverpool, Manchester United, Manchester City, Chelsea and Tottenham face some difficult away matches.