The Dutch champions swept the Premier League holders aside with ease on Wednesday night.
“It was probably my fault because I prepared badly for this game,” Mancini said.
“I didn’t prepare the players and I’m at fault. When you prepare for a game sometimes it is a different to what you expect. Sometimes you think the game goes one way and it goes another. We played a bad game. We had a few chances to score but the players didn’t really play well.”
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The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.
Five English clubs will compete in the last sixteen of the Champions League for the first time ever as Liverpool, Manchester United, Manchester City, Chelsea and Tottenham face some difficult away matches.