Arsenal travel to City to test their title credentials after a promising start to the season, and Mannone could stand in again in goal for Wojciech Szczesny.
“I thought we were in a good state at Liverpool because we went to a big game in a big stadium and from there we really started our season.
“City are champions so we know we have to go there and prepare properly. We must dictate the game because they are a great team and it will be a top challenge.”
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The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.
Five English clubs will compete in the last sixteen of the Champions League for the first time ever as Liverpool, Manchester United, Manchester City, Chelsea and Tottenham face some difficult away matches.