Barcelona were humbled by the German side and were unable to call on the Argentine superstar for the second leg last night.
Pique said: “The fact Lionel Messi, the best player in the world, did not play was a factor. But I do not think [he] would have changed things all that much.”
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After a dreadful start to their Bundesliga campaign, Borussia Dortmund appear to have weathered the storm after going five matches without defeat.