Barcelona were humbled by the German side and were unable to call on the Argentine superstar for the second leg last night.
Pique said: “The fact Lionel Messi, the best player in the world, did not play was a factor. But I do not think [he] would have changed things all that much.”
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Since Guus Hiddink arrived at the helm, Chelsea have improved considerably after a tricky start to the campaign.
Newcastle United are staring down the barrel of relegation to the Championship for the second time in the past eight years.