Barcelona were humbled by the German side and were unable to call on the Argentine superstar for the second leg last night.
Pique said: “The fact Lionel Messi, the best player in the world, did not play was a factor. But I do not think [he] would have changed things all that much.”
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The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.
Five English clubs will compete in the last sixteen of the Champions League for the first time ever as Liverpool, Manchester United, Manchester City, Chelsea and Tottenham face some difficult away matches.