The win at El Riazor means that Barcelona are three points ahead of Atletico Madrid, who play Real Sociedad on Sunday.
Messi’s hat trick moves him to within four goals of Pele’s record for goals in a calendar year.
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Who of Europe’s top strikers will move to England this summer?
After a dreadful start to their Bundesliga campaign, Borussia Dortmund appear to have weathered the storm after going five matches without defeat.