The win at El Riazor means that Barcelona are three points ahead of Atletico Madrid, who play Real Sociedad on Sunday.
Messi’s hat trick moves him to within four goals of Pele’s record for goals in a calendar year.
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Chelsea have struggled to build momentum in the opening stages of the campaign and are currently looking over their shoulders at the relegation zone.
Who of Europe’s top strikers will move to England this summer?