Messi scored Barcelona’s second and third goals, following an opener from David Villa.
Vallecano pulled one back but Barcelona are still 13 points clear now and remain on course for a La Liga record points haul.
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The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.
Five English clubs will compete in the last sixteen of the Champions League for the first time ever as Liverpool, Manchester United, Manchester City, Chelsea and Tottenham face some difficult away matches.