Messi scored Barcelona’s second and third goals, following an opener from David Villa.
Vallecano pulled one back but Barcelona are still 13 points clear now and remain on course for a La Liga record points haul.
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Who of Europe’s top strikers will move to England this summer?
After a dreadful start to their Bundesliga campaign, Borussia Dortmund appear to have weathered the storm after going five matches without defeat.