Mexico were frustrated for long spells against Trinidad and Tobago but eventually prevailed with a Raul Jimenez strike late on.
Panama had a far easier time of it, beating Cuba 6-1 to cruise into the last four of the competition.
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Since Guus Hiddink arrived at the helm, Chelsea have improved considerably after a tricky start to the campaign.
Newcastle United are staring down the barrel of relegation to the Championship for the second time in the past eight years.