Gabriel Torres struck twice for Panama to heap more pressure on Mexico coach Jose Manuel de la Torre.
Martinique also inflicted major shock on the opening day of the tournament as they beat Canada 1-0.
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Summer 2016 is set to be a very exciting time for football fans, as this is when the long awaited Euro 2016 tournament kicks off.
Since Guus Hiddink arrived at the helm, Chelsea have improved considerably after a tricky start to the campaign.