Casillas is out with a broken hand, although he was dropped by Mourinho before the injury, with speculation suggesting there is a major feud between the pair.
“I cannot say that a player will hold [on to a position] until the end of the season,” said Mourinho.
“But I will say that again Diego Lopez has played a big game and helped the team get a result.
“In football, we have to try and be honest with yourself and with your players.
“Along that line, it will be hard for Diego to come out of goal.”
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The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.
Five English clubs will compete in the last sixteen of the Champions League for the first time ever as Liverpool, Manchester United, Manchester City, Chelsea and Tottenham face some difficult away matches.