Dos Santos has failed to make an impact since joining the club in June 2008, playing only 10 Premier League games.
The Mexican playmaker is expected to leave White Hart Lane in the January transfer window.
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The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.
Five English clubs will compete in the last sixteen of the Champions League for the first time ever as Liverpool, Manchester United, Manchester City, Chelsea and Tottenham face some difficult away matches.