The Italian side need to avoid defeat against Borussia Dortmund in order to seal progress to the next round of the Champions League.
Hamsik suffered a foot injury during Napoli’s shock loss to Parma on Saturday.
Hamsik missed training on Sunday and will not be included in Rafa Benitez’s squad for the clash with Borussia Dortmund.
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The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.
Five English clubs will compete in the last sixteen of the Champions League for the first time ever as Liverpool, Manchester United, Manchester City, Chelsea and Tottenham face some difficult away matches.