Arsenal won 2-1 in the first leg of their Champions League last-16 tie in February.
"I've never played in the Nou Camp before and this will be one of the most exciting nights of my career," said Fabregas in The Sun.
"To finally have the chance to take to the pitch at this mythical stadium is something I cannot fully describe.
"The feeling is enormous and incredibly exciting."
"We have played so many games where we shown we have character, we have potential and that we are the present," continued Fabregas.
"We want to win things for the club and this is obviously a fantastic exam for all of us a team and individually."
He said: "I believe it is a big boost for Arsenal that two of my close friends - Carles Puyol and Gerard Pique - are not playing this evening as the former is injured while the latter is suspended."
He added: "We should not rest on our victory in the first leg. The job is not finished by a long way.
"In the first leg we proved once again we have guts and character. But it's only the halfway stage. All that hard work and effort means nothing, absolutely nothing, if we don't finish the job off."