AC Milan lost 1-0 at the San Siro in the first leg of their Champions League last-16 tie in February.
Spurs boss Harry Redknapp claimed after the game that the Premier League was superior to the Serie A.
"Everyone is entitled to their opinion and I respect his opinion, but I don't think he's right to say that," Flamini told the Daily Mail about Redknapp.
"It was only last season that Inter Milan won the Champions League. And this is a club with great history, great success and some great players.
"I have played in both England and Italy and the football is different. The Premier League is fast and furious from the first minute to the last. It is very strong, very quick.
"The Italian league is slower but more tactical. There is less space, and because of that it is harder to score goals.
"It is easier to beat the teams at the bottom of the league in England than it is in Italy. The Italian league is strong too.
"We lost 1-0 to Tottenham but I don't think we deserved to lose that game. We will go there and fight for the place in the quarter-finals and I am very confident we can do that.
"Like I said, I respect him (Redknapp) as a manager and as a person. Everyone has his opinion. But I have mine and, from what I have seen from the first leg, I am very confident we can win the game."