Pepe had a go at Mourinho for his treatment of Iker Casillas, but the Portuguese has responded in scathing terms towards his defender.
"You just have to be a normal person like me or like almost everyone in this room to know that we are talking about frustration," Mourinho said.
"His problem has a name: Raphael Varane. It's not easy for a man of 31 years, with status and history, to be trampled over by a kid of 19. But that's the law of life. On a sporting level Pepe's life has changed.
"I have no problem with him. I understand that it's not an easy situation but I have to try to be honest and I think that there are very few people who don't think that the future of Real Madrid in defence is Varane with Sergio Ramos."