Barcelona have been linked with a number og goalkeepers recently and Guzman is keen to be reunited with Gerardo Martino at the Spanish side.
"Obviously, it would be a dream to join Barcelona. It is clear that I have that illusion," he told El Mundo Deportivo.
"To be part of a team like Barca would be very nice, a dream.
"Now my challenge is to sustain what I have been doing at Newell's. After achieving a championship, the most difficult thing is to maintain that level personally and in the team."
"He is a very special technician. I have learned a lot from him and his assistants," he said of Martino.
"He is a great person, which is perhaps more important than the kind of coach he is. He greatly impressed me and also managed a championship."